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TSPO Antikörper (C-Term)

TSPO Reaktivität: Human WB, IHC (p) Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN452349
  • Target Alle TSPO Antikörper anzeigen
    TSPO (Peripheral-Type Benzodiazepine Receptor (TSPO))
    Bindungsspezifität
    • 15
    • 6
    • 5
    • 4
    • 1
    • 1
    C-Term
    Reaktivität
    • 38
    • 28
    • 19
    Human
    Wirt
    • 47
    • 5
    • 2
    Ziege
    Klonalität
    • 40
    • 14
    Polyklonal
    Konjugat
    • 22
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TSPO Antikörper ist unkonjugiert
    Applikation
    • 21
    • 17
    • 14
    • 13
    • 12
    • 8
    • 8
    • 6
    • 5
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Sequenz
    c-RDNHGWRGGR RLPE
    Spezifität
    This antibody is expected to recognise one isoform of TSPO/PBR (NP_000705.2) only.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide with sequence from the C Terminus of the protein sequence according to NP_000705.2. Genename: TSPO
    Top Product
    Discover our top product TSPO Primärantikörper
  • Applikationshinweise
    Peptide ELISA: Detection Limit: 1/128000. Western blot: 0.1-0.3 μg/mL. Approx 35 kDa band observed in Human Brain lysates(calculated MW of 18.5 kDa according to NP_000705.2). Immunohistochemistry: 2-4 μg/mL. In paraffin embedded Human Colon shows strongcytoplasm staining of absorptive cells.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    TSPO (Peripheral-Type Benzodiazepine Receptor (TSPO))
    Andere Bezeichnung
    TSPO / BZRP (TSPO Produkte)
    Synonyme
    LOC732875 antikoerper, LOC100136652 antikoerper, LOC100280949 antikoerper, BZRP antikoerper, TSPO antikoerper, Bzrp antikoerper, IBP antikoerper, PBR antikoerper, Tspo1 antikoerper, MBR antikoerper, PTBZR02 antikoerper, Ptbzr antikoerper, RATPTBZR02 antikoerper, BPBS antikoerper, DBI antikoerper, PBS antikoerper, PKBS antikoerper, PTBR antikoerper, mDRC antikoerper, pk18 antikoerper, peripheral-type benzodiazepine receptor antikoerper, Peripheral-type benzodiazepine receptor antikoerper, putative peripheral-type benzodiazepine receptor antikoerper, translocator protein antikoerper, translocator protein homolog antikoerper, hypothetical protein antikoerper, LOC732875 antikoerper, MAV_3896 antikoerper, xccb100_2086 antikoerper, Smp_102510 antikoerper, Sros_1911 antikoerper, tspo antikoerper, LOC100280949 antikoerper, PGTG_16395 antikoerper, TSPO antikoerper, Tspo antikoerper
    Hintergrund
    PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.Synonyms: MBR, Mitochondrial benzodiazepine receptor, PBR, PKBS, Peripheral-type benzodiazepine receptor, Translocator protein
    Gen-ID
    706
    NCBI Accession
    NP_000705
    UniProt
    P30536
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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