C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Antikörper

Antigen: C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf)

Synonyme: VEGFD, VEGF-D, FIGF, vegfd, vegf-d, Vegfd, AI325264, Vegf-d

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN411622

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-human VEGF-D polyclonal antibody. Detects ~35 kDa human VEGF-D in Western blot analysis. Recombinant human VEGF-D (Cat.# 4643-10) can be used as a positive control.

Weitere Bezeichnung: VEGF-D

Gen-ID: 2277

Immunogen: E. coli expressed human VEGF-D

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: EGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. The recombinant VEGF-D as the immunogen was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human VEGF-D (Cat.# 4643-10) can be used as a positive control. Other applications have not been determined.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit anti- VEGF-D polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Beschränkungen: Nur für Forschungszwecke einsetzbar