Signal Transducer and Activator of Transcription 2 (STAT2) Antikörper

Antigen: Signal Transducer and Activator of Transcription 2 (STAT2)

Synonyme: P113, ISGF-3, STAT113, MGC59816, STAT2, p113, isgf-3, stat113

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN411595

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-Stat2 polyclonal antibody. Detects ~110 kDa Stat2 in samples of human/mouse/rat origins. Tested in Western blot. Other applications have not been determined. Blocking peptide (Cat.# 3468BP-50) is available separately.

Weitere Bezeichnung: Stat2

Gen-ID: 6773

Immunogen: Synthetic peptide surrounding amino acid 615 of rat Stat2

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Spezifität: The antibody recognizes ~113 kDa of Stat2 from samples of human, mouse and rat origins. Reactivity to other species has not been determined.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml), However, the optimal concentrations should be determined individually. The antibody recognizes ~113 kDa of Stat2 from samples of human, mouse and rat origins. Reactivity to other species has not been determined.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Forschungsgebiet: Chromatin und nukleäre Signaltransduktion, Transkriptionsfaktoren, Signaltransduktion, Rezeptoren, Inflammation

Beschränkungen: Nur für Forschungszwecke einsetzbar