Phospho-IRS (Ser616) Antikörper

Antigen: Phospho-IRS

Epitope: Ser616

Klonalität: Monoklonal (HIR-B1)

Wirt: Maus

Reaktivität: Human

Applikation: Indirektes ELISA (iELISA), Western Blot (WB)

Produktnummer: ABIN411558

Produktbeschreibung

Produktmerkmale: 100 µg (1.0 mg/ml) affinity purified antibody. Reacts with human. Tested in indirect ELISA and WB.

Weitere Bezeichnung: Phospho-IRS (Ser616)

Gen-ID: 3667

Immunogen: Synthetic peptide phosphorylated at Ser 616 site

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: HIR-B1

Beschreibung: Insulin receptor substrates (IRS) subtypes are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. The balance between Ser/Thr phosphorylation of IRS has been demonstrated to be an important regulator of insulin signaling. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm’s tumors, and adrenal cortical carcinomas. Does not recognize IRS peptide NOT phosphorylated at Ser616 and will not recognize IRS peptide phosphorylated at Tyr183. Also does not react with riboflavin carrier protein which is known to have multiple phosphate groups.

Anwendungen

Applikationshinweise: The antibody can be used for indirect ELISA and WB.

Konzentration: 1.0 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (1.0 mg/ml) purified mouse monoclonal antibody supplied in PBS with 0.05% (W/V) sodium azide.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Beschränkungen: Nur für Forschungszwecke einsetzbar