Paired Box 6 (PAX6) Antikörper

Antigen: Paired Box 6 (PAX6)

Synonyme: AN, AN2, MGDA, WAGR, D11S812E, MGC17209, Dey, Sey, AEY11, Pax-6, Gsfaey11, 1500038E17Rik, pax-6, an2, mgda, wagr, pax6a, xpax6, XLPAX6, MGC52531, PAX6, pax6, pax6b, PAX-6

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN411553

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-PAX6 polyclonal antibody. Reacts with human/mouse/rat. Other species have not been determined. Tested in Western blot analysis. Blocking peptide (Cat.# 3636RBP-50) is available separately.

Weitere Bezeichnung: PAX6

Gen-ID: 25509

Immunogen: Synthetic peptide surrounding amino acid 303 of rat PAX6

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: PAX genes encode nuclear transcription factors that may function as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes (aniridia, foveal hypoplasia and Peters’ anomaly). Murine PAX genes have been shown to be proto-oncogenes. Furthermore, human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3, another important visual development protein.

Spezifität: The antibody recognizes ~32 kDa and 47 kDa isoforms of PAX6 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~32 kDa and 47 kDa isoforms of PAX6 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Forschungsgebiet: Organogenese, Abstammungsmarker, Transkriptionsfaktoren, Neuronale Stammzellmarker

Beschränkungen: Nur für Forschungszwecke einsetzbar