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Insulin Induced Gene 1 (INSIG1) Antikörper

Antigen

Insulin Induced Gene 1 (INSIG1)
Synonyme CL6, CL-6, MGC1405, Insig-1, 1810013C12Rik, fb55a03, fi35b10, zgc:55439, wu:fb55a03, wu:fi35b10, insig1, MGC84597, INSIG1, MGC142724, cl-6, MGC147122
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human, Maus, Ratte (Rattus), Rind (Kuh), Hamster
Applikation
Alternativen Western Blot (WB)
Produktnummer ABIN411520
Menge 100 µg  (0.5 mg/ml)
Preis 276,63 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper zurück nach oben

Produktmerkmale 100 ug affinity purified rabbit anti-Insig1 polyclonal antibody. Reacts with human/mouse/rat/bovine/hamster. Tested in Western blot. Other applications have not been determined. Blocking peptide (Cat.# 3854BP-50) is also available separately.
Weitere Bezeichnung Insig1
Gen-ID 64194
Immunogen Synthetic peptide surrounding amino acid 248 of rat Insig1
Isotyp IgG  (Passende Sekundärantikörper)
Beschreibung Insulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Spezifität The antibody recognizes ~30 kDa InSig-1 and its precursor (~50 kDa) in samples from human, mouse and rat origins. Reactivity to other species has not been tested.

Anwendungen
Alternativen Sekundärantikörper zurück nach oben

Applikationshinweise Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~30 kDa InSig-1 and its precursor (~50 kDa) in samples from human, mouse and rat origins. Reactivity to other species has not been tested.
Konzentration 0.5 mg/ml
Reinigung Affinity Purified Antibody
Buffer 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Lagerung Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.
Forschungsgebiet Signaltransduktion
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper zurück nach oben

Alternativen zu Antigen "Insulin Induced Gene 1 (INSIG1)", Typ "Antikörper" finden
Wirte Kaninchen (38)
Reaktivitäten Human (32), Maus (22), Ratte (Rattus) (21), Rind (Kuh) (5), Hund (3), Schwein (3), Huhn (2), Meerschweinchen (1), Kaninchen (1), Schaf (1)
Applikationen Western Blot (WB) (21), Durchflusszytometrie (FACS) (18), Immunfluoreszenz (IF) (18), ELISA (5), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunhistochemie (Paraffinschnitte) (IHC (p)) (2), Immunpräzipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
Konjugate Biotin (2), HRP (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)