CCR3 Antikörper

Antigen: CCR3

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN411449

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in Western blot analysis. Blocking peptide is available separately.

Gen-ID: 117027

Immunogen: Synthetic peptide surrounding amino acid 332 of rat CCR3

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR3 (eotaxin receptor), is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin, including RANTES, monocyte chemotactic protein (MCP)-2, MCP-3, and MCP-4. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, and inhibited infection by these isolates.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) Protein G purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Forschungsgebiet: Signaltransduktion, Angeborene Immunität, Chemokine, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar