BMI-1 Antikörper

Antigen: BMI-1

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus), Rind (Kuh), Hund, Katze

Applikation: Western Blot (WB)

Produktnummer: ABIN411436

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-BMI-1 polyclonal antibody. Reacts with human/mouse/rat/bovine/dog/cat. Detects 34 kDa PMI-1 in Western blot analysis. Other applications have not been determined. Blocking peptide (Cat.# 3930BP-50) is available separately.

Gen-ID: 307151

Immunogen: Synthetic peptide surrounding amino acid 312 of rat BMI-1

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Polycomb group (PcG) genes encode chromatin proteins that are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Bmi-1 has been identified among the PcG genes as a potent oncogene that plays an important role in the regulation of cell proliferation by suppressing the p16-dependant pathway. Bmi-1 may be use as a therapeutic target for studying stem cell proliferation and renewal.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~34 kDa of Bmi-1 in Jurkat cell lysate and rat kidney tissue lysate. Reactivity to other species has not been tested.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Beschränkungen: Nur für Forschungszwecke einsetzbar