Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Antikörper

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyme: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN411430

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-BAFF-R polyclonal antibody. Reacts with human/mouse/rat samples. Performed well in Western blot. Other applications have not been tested. Blocking peptide (Cat.# 3578RBP-50) is available separately.

Weitere Bezeichnung: BAFF-R

Gen-ID: 631763

Immunogen: Synthetic peptide surrounding amino acid 159 of mouse BAFF-R

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-Jun N-terminal kinase.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 100 µg (0.5 mg/ml) affinity purified rabbit anti-BAFF-R polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Beschränkungen: Nur für Forschungszwecke einsetzbar