ATG7 Autophagy Related 7 Homolog (S. Cerevisiae) (ATG7) Antikörper

Antigen: ATG7 Autophagy Related 7 Homolog (S. Cerevisiae) (ATG7)

Synonyme: atg7, D8, UBE2, UBA1B, UBE1L, MGC12713, MOP-4, UBE1L2, FLJ10808, FLJ23367, Uba7, 1300004C08Rik, Ube1l, Ube1l2, RGD1308324, UBA7, UBE1, UBA6

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Western Blot (WB)

Produktnummer: ABIN411424

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-APG7/ATG7 polyclonal antibody. Reacts with human/mouse. Tested in Western blot. Other applications have not been determined.

Weitere Bezeichnung: APG7/ATG7

Gen-ID: 312647

Immunogen: Synthetic peptide near the N-terminus of rat APG7

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 0.5 mg/ml affinity purified rabbit anti-APG7/ATG7 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Beschränkungen: Nur für Forschungszwecke einsetzbar