ATG12 Autophagy Related 12 Homolog (S. Cerevisiae) (ATG12) Antikörper

Antigen: ATG12 Autophagy Related 12 Homolog (S. Cerevisiae) (ATG12)

Synonyme: APG12, FBR93, APG12L, HAPG12, atg12, CG10861, DmelCG10861, Apg12l, Atg12l, 4931423H11Rik, A330058M13Rik, MGC125080, ATG12, MGC127276, APG12B, AUTOPHAGY 12, AUTOPHAGY 12 B, ATG12A, AUTOPHAGY 12 A, F20D21.38, F20D21_38, DKFZp459D2226

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN411421

Produktbeschreibung

Produktmerkmale: 100 ug affinity purified rabbit anti-APG12/ATG12 polyclonal antibody. Reacts with human/mouse/rat. Tested in Western blot. Other applications have not been determined.

Weitere Bezeichnung: APG12/ATG12

Gen-ID: 67526

Immunogen: Synthetic peptide surrounding amino acid 21 of mouse APG12

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

Synonyme: APG12, FBR93, APG12L, HAPG12, atg12, CG10861, DmelCG10861, Apg12l, Atg12l, 4931423H11Rik, A330058M13Rik, MGC125080, ATG12, MGC127276, APG12B, AUTOPHAGY 12, AUTOPHAGY 12 B, ATG12A, AUTOPHAGY 12 A, F20D21.38, F20D21_38, DKFZp459D2226

Anwendungen

Applikationshinweise: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.

Konzentration: 0.5 mg/ml

Reinigung: Affinity Purified Antibody

Buffer: 0.5 mg/ml affinity purified rabbit anti-APG12 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.

Lagerung: Store at -20°C. Shelf life: 12 months. The antibody solution should be gently mixed before use.

Beschränkungen: Nur für Forschungszwecke einsetzbar