EN1 Antikörper (C-Term)

Produktnummer ABIN406781

Produktdetails anti-EN1 Antikörper

Target: EN1 (Engrailed Homeobox 1 (EN1))

Bindungsspezifität: C-Term

Reaktivität: Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LMGSANGGPV VKTDSQQPLV WPAWVYCTRY SDRPSSGPRT RKLKKKKNEK

Kreuzreaktivität: Huhn, Human, Maus

Homologie: Guinea Pig: 93%, Rabbit: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against EN1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EN1

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-EN1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 392 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-EN1 Antikörper (ABIN406781)

Beltran, Graves, Blancafort: "Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function." in: Oncogene, Vol. 33, Issue 39, pp. 4767-77, (2014) (PubMed).

Details zu EN1

Target: EN1 (Engrailed Homeobox 1 (EN1))

Andere Bezeichnung: Engrailed-1 / EN1 (EN1 Produkte)

Synonyme: EN1 antikoerper, En-1 antikoerper, Mo-en.1 antikoerper, ENG-1 antikoerper, en-1 antikoerper, en1 antikoerper, eng1 antikoerper, zgc:100771 antikoerper, en1-A antikoerper, engrailed-1 antikoerper, xen1 antikoerper, Gg-En-1 antikoerper, en-3 antikoerper, engrailed antikoerper, engrailed homeobox 1 antikoerper, engrailed 1 antikoerper, engrailed homeobox 1a antikoerper, engrailed homeobox 1 S homeolog antikoerper, EN1 antikoerper, En1 antikoerper, en1a antikoerper, en1.S antikoerper

Hintergrund: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: TLE1, PAX6, JUN,
Protein Size: 392

Molekulargewicht: 40 kDa

Gen-ID: 2019

NCBI Accession: NM_001426, NP_001417

UniProt: Q05925

Pathways: Dopaminergic Neurogenesis