MARCH4 Antikörper (N-Term)

Produktnummer ABIN405545

Produktdetails anti-MARCH4 Antikörper

Target: MARCH4 (Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein Ligase (MARCH4))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GLLKCRCRML FNDLKVFLLR RPPQAPLPMH GDPQPPGLAA NNTLPALGAG

Homologie: Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 85%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against MARCH4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MARCH4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 410 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MARCH4

Target: MARCH4 (Membrane-Associated Ring Finger (C3HC4) 4, E3 Ubiquitin Protein Ligase (MARCH4))

Andere Bezeichnung: MARCH4 (MARCH4 Produkte)

Synonyme: MARCH-IV antikoerper, RNF174 antikoerper, BC056494 antikoerper, mKIAA1399 antikoerper, MARCH4 antikoerper, si:ch211-239d11.2 antikoerper, membrane associated ring-CH-type finger 4 antikoerper, membrane-associated ring finger (C3HC4) 4 antikoerper, MARCH4 antikoerper, March4 antikoerper, march4 antikoerper

Hintergrund: MARCH4 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Alias Symbols: MARCH-IV, MGC104908, RNF174
Protein Interaction Partner: UBE2H, UBE2D1, ULBP1, CD4,
Protein Size: 410

Molekulargewicht: 45 kDa

Gen-ID: 57574

NCBI Accession: NM_020814, NP_065865

UniProt: Q9P2E8