PARP11 Antikörper (Middle Region)

Produktnummer ABIN404898

Produktdetails anti-PARP11 Antikörper

Target: PARP11 (Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IKHGNTFQIH GVSLQQRHLF RTYKSMFLAR VLIGDYINGD SKYMRPPSKD

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PARP11. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PARP11

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 331 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PARP11

Target: PARP11 (Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))

Andere Bezeichnung: PARP11 (PARP11 Produkte)

Synonyme: 5330431N24Rik antikoerper, AI851877 antikoerper, ARTD11 antikoerper, HIN1L antikoerper, C12orf6 antikoerper, parp11 antikoerper, MGC82612 antikoerper, PARP11 antikoerper, RGD1561791 antikoerper, poly (ADP-ribose) polymerase family, member 11 antikoerper, poly(ADP-ribose) polymerase family member 11 antikoerper, poly(ADP-ribose) polymerase family member 11 S homeolog antikoerper, poly(ADP-ribose) polymerase family member 11 L homeolog antikoerper, Parp11 antikoerper, PARP11 antikoerper, parp11.S antikoerper, parp11.L antikoerper, parp11 antikoerper

Hintergrund: PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.
Alias Symbols: C12orf6, DKFZp779H0122
Protein Interaction Partner: MDFI, TRIP13, DCAF11, RNF114, OTUD4, LYZ, GTPBP3, NUP98,
Protein Size: 331

Molekulargewicht: 39 kDa

Gen-ID: 57097

NCBI Accession: NM_020367, NP_065100

UniProt: Q9NR21