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MXI1 Antikörper (Middle Region)

MXI1 Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN404744
  • Target Alle MXI1 Antikörper anzeigen
    MXI1 (MAX Interactor 1 (MXI1))
    Bindungsspezifität
    • 8
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 35
    • 33
    • 17
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae, Pferd
    Wirt
    • 41
    • 4
    • 2
    Kaninchen
    Klonalität
    • 43
    • 4
    Polyklonal
    Konjugat
    • 26
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MXI1 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 22
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    QGPQEMERIR MDSIGSTISS DRSDSEREEI EVDVESTEFS HGEVDNISTT
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 79%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%, Zebrafish: 77%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MXI1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human MXI1
    Top Product
    Discover our top product MXI1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 295 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MXI1 (MAX Interactor 1 (MXI1))
    Andere Bezeichnung
    MXI1 (MXI1 Produkte)
    Synonyme
    mxi antikoerper, mad2 antikoerper, mxd2 antikoerper, xmxi1 antikoerper, MGC89544 antikoerper, MXI1 antikoerper, etID309773.22 antikoerper, fb16b12 antikoerper, fb55f03 antikoerper, wu:fb16b12 antikoerper, wu:fb55f03 antikoerper, wu:fd06a08 antikoerper, wu:fz74f10 antikoerper, ENSMUSG00000067085 antikoerper, Gm10197 antikoerper, Mad2 antikoerper, bHLHc11 antikoerper, MXI-WR antikoerper, MAD2 antikoerper, MXD2 antikoerper, MXI antikoerper, MAX interactor 1, dimerization protein antikoerper, max interactor 1, dimerization protein antikoerper, MAX interactor 1, dimerization protein L homeolog antikoerper, mxi1 antikoerper, MXI1 antikoerper, Mxi1 antikoerper, mxi1.L antikoerper
    Hintergrund
    Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
    Alias Symbols: MAD2, MGC43220, MXD2, MXI, bHLHc11
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-5, KRTAP10-9, KRTAP10-7, KRT40, RPL23AP32, CALCOCO2, MAX, ENTPD5, UBC, APP, CDC20, BUB1B, SIN3B, SIN3A, SMC3, MYC,
    Protein Size: 295
    Molekulargewicht
    33 kDa
    Gen-ID
    4601
    NCBI Accession
    NM_130439, NP_569157
    Pathways
    Maintenance of Protein Location
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