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DARPP32 Antikörper (pThr75)
PPP1R1B
Reaktivität: Human, Maus, Ratte
IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-DARPP32 Antikörper
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Target
Alle DARPP32 (PPP1R1B) Antikörper anzeigen
DARPP32 (PPP1R1B)
(Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B))
Bindungsspezifität
Alle Epitope für DARPP32 Antikörper
pThr75
Reaktivität
Alle Reaktivitäten für DARPP32 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für DARPP32 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für DARPP32 Antikörper
Polyklonal
Konjugat
Alle Konjugate für DARPP32 Antikörper
Dieser DARPP32 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für DARPP32 Antikörper
Immunofluorescence (IF)
Spezifität
DARPP-32 (Phospho-Thr75) Antibody detects endogenous levels of DARPP-32 only when phosphorylated at threonine 75.
Aufreinigung
Affinity chromatography
Immunogen
Synthesized phosphopeptide derived from human DARPP-32 around the phosphorylation site of threonine 75 (A-Y-TP-P-P).
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Anwendungsinformationen
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Applikationshinweise
Immunofluorescence: 1/100 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Details zu DARPP32
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Target
DARPP32 (PPP1R1B)
(Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B))
Andere Bezeichnung
DARPP32 (PPP1R1B Produkte )
Synonyme
darpp32 antikoerper, darpp-32 antikoerper, Darpp-32 antikoerper, Darpp32 antikoerper, DARPP-32 antikoerper, DARPP32 antikoerper, AU040756 antikoerper, protein phosphatase 1 regulatory inhibitor subunit 1B antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 1B antikoerper, protein phosphatase 1 regulatory inhibitor subunit 1B S homeolog antikoerper, ppp1r1b antikoerper, PPP1R1B antikoerper, Ppp1r1b antikoerper, ppp1r1b.S antikoerper
Hintergrund
DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 and phosphorylated DARPP32 is a potent protein phosphatase 1. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho DARPP32, thereby reducing the phosphatase 1 inhibitory activity of DARPP32.Synonyms: DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein, FLJ20940, PPP1R1B, Protein phosphatase 1 regulatory subunit 1B
Gen-ID
84152
NCBI Accession
NP_115568
UniProt
Q9UD71
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