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Cofilin Antikörper (pTyr88)

CFL1 Reaktivität: Human, Maus, Ratte IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401589
  • Target Alle Cofilin (CFL1) Antikörper anzeigen
    Cofilin (CFL1) (Cofilin 1 (CFL1))
    Bindungsspezifität
    • 18
    • 16
    • 16
    • 15
    • 12
    • 12
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr88
    Reaktivität
    • 144
    • 97
    • 94
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 148
    • 10
    • 2
    Kaninchen
    Klonalität
    • 148
    • 11
    Polyklonal
    Konjugat
    • 73
    • 12
    • 12
    • 9
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Dieser Cofilin Antikörper ist unkonjugiert
    Applikation
    • 80
    • 70
    • 47
    • 47
    • 41
    • 41
    • 32
    • 30
    • 16
    • 13
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Antibody AP09484PU detects endogenous levels of Cofilin-1/Cofilin-2 only when phosphorylated at Tyrosine 88.
    Aufreinigung
    Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human Cofilin-1/Cofilin-2 around the phosphorylation site of Tyrosine 88 (A-T-Yp-E-T).
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    Discover our top product CFL1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry on Paraffin Sections: 1/50approx. 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    Cofilin (CFL1) (Cofilin 1 (CFL1))
    Andere Bezeichnung
    Cofilin-1 (CFL1 Produkte)
    Synonyme
    cfl1 antikoerper, xac1 antikoerper, xac2 antikoerper, cfl antikoerper, cb86 antikoerper, sb:cb86 antikoerper, zgc:56501 antikoerper, wu:fb18a04 antikoerper, wu:fk77b03 antikoerper, 12/8 antikoerper, ADF antikoerper, ADF/cofilin antikoerper, Adf antikoerper, CG4254 antikoerper, Cadf antikoerper, D-cof antikoerper, D61 antikoerper, Dmel\\CG4254 antikoerper, T8 antikoerper, Tsr antikoerper, cofilin antikoerper, cofilin/ADF antikoerper, cofilin/actin depolymerizing factor homolog antikoerper, l(2)03101 antikoerper, l(2)k03101 antikoerper, l(2)k05633 antikoerper, l(2)k13409 antikoerper, ntf antikoerper, CFL antikoerper, AA959946 antikoerper, Cof antikoerper, CFL1 antikoerper, cofilin 1 (non-muscle) L homeolog antikoerper, cofilin 1 (non-muscle) antikoerper, cofilin 1 (non-muscle), like antikoerper, cofilin 1 antikoerper, twinstar antikoerper, cofilin antikoerper, cofilin 1, non-muscle antikoerper, Contrafreeloading antikoerper, cfl1.L antikoerper, cfl1 antikoerper, cfl1l antikoerper, CFL1 antikoerper, tsr antikoerper, COF1 antikoerper, TSTA_042790 antikoerper, Cfl1 antikoerper, CFL antikoerper
    Hintergrund
    Cofilin is a small phosphoinositide sensitive, actin binding protein capable of depolymerizing actin filaments in vitro. Under certain conditions, it fragments the filaments and accelerates actin subunit dissociation from their 'pointed' (minus) ends. Cofilin binds stoichiometrically to monomeric G-actin and to actin protomers in filaments in an apparent pH -dependent, Ca2+- independent manner. Cofilin intercalates between longitudinally associated actin monomers within the filament and distorts its helical twist. Cofilin is ubiquitous in tissues of eukaryotes and is especially abundant in neuronal tissues. It is essential for viability and is important for many cellular processes involving actin remodeling such as motility at the leading edge of cells, polarized cell growth, endocytosis, phagocytosis, cellular activation, cytokinesis, and pathogen intracellular motility.Synonyms: 18 kDa phosphoprotein, CFL, CFL1, Cofilin non-muscle isoform, p18
    Gen-ID
    1072
    NCBI Accession
    NP_005498
    UniProt
    P23528
    Pathways
    Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus, CXCR4-mediated Signaling Events
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