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TRKB Antikörper (pTyr515)

NTRK2 Reaktivität: Human, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401582
  • Target Alle TRKB (NTRK2) Antikörper anzeigen
    TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
    Bindungsspezifität
    • 16
    • 15
    • 12
    • 12
    • 10
    • 10
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr515
    Reaktivität
    • 135
    • 92
    • 87
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 140
    • 9
    • 4
    • 1
    • 1
    Kaninchen
    Klonalität
    • 132
    • 23
    Polyklonal
    Konjugat
    • 86
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser TRKB Antikörper ist unkonjugiert
    Applikation
    • 111
    • 55
    • 50
    • 21
    • 19
    • 18
    • 15
    • 14
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF)
    Spezifität
    Antibody AP09481PU detects endogenous levels of TrkB only when phosphorylated at Tyrosine 515.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse and Rat
    Aufreinigung
    Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from Human TrkB around the phosphorylation site of Tyrosine 515 (P-Q-Y-pF-G).
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  • Applikationshinweise
    Immunofluorescence: 1/100approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
    Andere Bezeichnung
    TrkB (NTRK2 Produkte)
    Synonyme
    trkb antikoerper, trkb-b antikoerper, xtrkb antikoerper, si:ch211-220b11.1 antikoerper, trkB2 antikoerper, NTRK2 antikoerper, ntrk2 antikoerper, gp145-trkb antikoerper, TRKB antikoerper, GP145-TrkB antikoerper, trk-B antikoerper, AI848316 antikoerper, C030027L06Rik antikoerper, Tkrb antikoerper, trkB antikoerper, RATTRKB1 antikoerper, TRKB1 antikoerper, Trk-B antikoerper, TrkB antikoerper, neurotrophic receptor tyrosine kinase 2 antikoerper, neurotrophic receptor tyrosine kinase 2 L homeolog antikoerper, neurotrophic tyrosine kinase, receptor, type 2b antikoerper, neurotrophic receptor tyrosine kinase 2 S homeolog antikoerper, neurotrophic tyrosine kinase, receptor, type 2 antikoerper, NTRK2 antikoerper, ntrk2.L antikoerper, ntrk2b antikoerper, ntrk2.S antikoerper, ntrk2 antikoerper, Ntrk2 antikoerper
    Hintergrund
    Neurotrophins activate tyrosine kinase receptors of the Trk family (TrkA, TrkB and TrkC) and they all share a common low affinity receptor (p75NTR or p75). Although p75NTR does not appear to directly transduce NGF signals, this receptor appears to increase the responsiveness of the trk receptors and plays a role in the retrograde transport of neurotrophin signals from axon terminals to the cell body. The expression of trk gene neurotrophin receptors in mouse is tabulated by Barbacid (1994). NGF binds with high affinity and activates the TrkA tyrosine kinase receptor, which is apparently responsible for signal transduction. BDNF activates the TrkB tyrosine kinase receptor, which it shares with NT-4. NT-3 activates the TrkC tyrosine kinase receptor, but can also activate TrkA and TrkB receptors in certain cell systems. NT-4 primarily activates the TrkB tyrosine kinase receptor, which it shares with BDNF.Synonyms: BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TRKB, TrkB tyrosine kinase
    Molekulargewicht
    140 kDa
    Gen-ID
    4915
    NCBI Accession
    NP_001007098
    UniProt
    Q16620
    Pathways
    RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
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