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SNCA Antikörper (pTyr136)

SNCA Reaktivität: Human, Ratte, Maus WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401576
  • Target Alle SNCA Antikörper anzeigen
    SNCA (Synuclein, alpha (SNCA))
    Bindungsspezifität
    • 73
    • 32
    • 27
    • 24
    • 16
    • 15
    • 13
    • 11
    • 11
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr136
    Reaktivität
    • 309
    • 209
    • 209
    • 14
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 247
    • 104
    • 6
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 231
    • 130
    Polyklonal
    Konjugat
    • 160
    • 25
    • 22
    • 17
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    Dieser SNCA Antikörper ist unkonjugiert
    Applikation
    • 252
    • 171
    • 113
    • 84
    • 80
    • 74
    • 68
    • 54
    • 49
    • 49
    • 23
    • 21
    • 13
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Spezifität
    This antibody detects endogenous levels of Alpha-Synuclein only when phosphorylated at Tyrosine 136.
    Aufreinigung
    Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide Sequence around the phosphorylation site of Tyr136 (Q-D-Yp-E-P) derived from Human Alpha-Synuclein
    Top Product
    Discover our top product SNCA Primärantikörper
  • Applikationshinweise
    Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/100approx. 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    SNCA (Synuclein, alpha (SNCA))
    Andere Bezeichnung
    alpha-Synuclein / SNCA (SNCA Produkte)
    Synonyme
    snca antikoerper, MGC64356 antikoerper, LOC619283 antikoerper, NACP antikoerper, alphaSYN antikoerper, PARK1 antikoerper, PARK4 antikoerper, PD1 antikoerper, synuclein alpha L homeolog antikoerper, alpha-synuclein antikoerper, synuclein alpha antikoerper, synuclein, alpha antikoerper, snca.L antikoerper, LOC619283 antikoerper, SNCA antikoerper, Snca antikoerper
    Hintergrund
    Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
    Gen-ID
    6622
    NCBI Accession
    NP_000336
    UniProt
    P37840
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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