MEF2A Antikörper (pThr319)

Produktnummer ABIN401542

Produktdetails anti-MEF2A Antikörper

Target: MEF2A (Myocyte Enhancer Factor 2A (MEF2A))

Bindungsspezifität: pThr319

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2A Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of MEF2A only when phosphorylated at Thr319.

Aufreinigung: Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from Human MEF2A around the phosphorylation site of Thr319 (V-T-TP-P-S).

Anwendungsinformationen

Applikationshinweise: Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at-20 °C.

Details zu MEF2A

Target: MEF2A (Myocyte Enhancer Factor 2A (MEF2A))

Andere Bezeichnung: MEF2A (MEF2A Produkte)

Synonyme: ADCAD1 antikoerper, RSRFC4 antikoerper, RSRFC9 antikoerper, mef2 antikoerper, A430079H05Rik antikoerper, mef2a antikoerper, wu:fd19d02 antikoerper, adcad1 antikoerper, rsrfc4 antikoerper, rsrfc9 antikoerper, sl2 antikoerper, MEF2A antikoerper, xmef2a antikoerper, myocyte enhancer factor 2A antikoerper, myocyte enhancer factor 2aa antikoerper, myocyte enhancer factor 2a antikoerper, myocyte-specific enhancer factor 2A antikoerper, myocyte-specific enhancer factor 2a, putative antikoerper, myocyte enhancer factor 2A L homeolog antikoerper, MEF2A antikoerper, Mef2a antikoerper, mef2aa antikoerper, EDI_092490 antikoerper, EDI_038250 antikoerper, Smp_161530 antikoerper, mef2a.L antikoerper, mef2a antikoerper, LOC539054 antikoerper

Hintergrund: The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5 and MRF-4, are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF-2) family. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.Synonyms: MEF2, Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1

Gen-ID: 4205

NCBI Accession: NP_001124398

UniProt: Q02078

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades