FANCF Antikörper (Internal Region)

Produktnummer ABIN401270

Der Kaninchen Polyklonal anti-FANCF Antikörper wird verwendet zum Nachweis von FANCF in Proben von Human und Schimpanse. Er wurde validiert für WB und EIA.

Kurzübersicht für FANCF Antikörper (Internal Region) (ABIN401270)

Target: FANCF (Fanconi Anemia, Complementation Group F (FANCF))

Reaktivität: Human, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-FANCF Antikörper

Bindungsspezifität: Internal Region

Spezifität: This affinity purified antibody is directed against FANCF protein.

Kreuzreaktivität (Details): Species reactivity (expected):Chimpanzee (100 %).
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity chromatography

Immunogen: Synthetic peptide corresponding to an internal amino acid sequence of human FANCF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 15,000 - 1: 60,000. Western blot: 1: 1,000 - 1: 5,000 (Expect a band approximately 42 kDa in size correspondingto FANCF in the appropriate human tissue).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.19 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Details zu FANCF

Target: FANCF (Fanconi Anemia, Complementation Group F (FANCF))

Andere Bezeichnung: FANCF

Hintergrund: FANCF (also called Protein FACF or Fanconi Anemia Group F protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCF belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. FANCF is found within the nucleus. Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FACF, Fanconi anemia group F protein

Gen-ID: 2188

NCBI Accession: NP_073562

UniProt: Q9NPI8

Pathways: DNA Reparatur