Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (N-Term) Antikörper

Antigen: Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7)

Synonyme: D8, UBE2, UBA1B, UBE1L, MGC12713, MOP-4, UBE1L2, FLJ10808, FLJ23367, Uba7, 1300004C08Rik, Ube1l, Ube1l2, RGD1308324, UBA7, UBE1, UBA6, xubc14, ube2s-C, xubc4, ube2d2, ube2d3.1, xubc3

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN400958

Produktbeschreibung

Produktmerkmale: Synonyms: Ubiquitin-activating enzyme 7, UBE2, Ubiquitin-like modifier-activating enzyme 7,Ubiquitin-activating enzyme E1 homolog

Weitere Bezeichnung: UBA7 / UBE1L

Swiss-Prot: P41226

Immunogen: UBE1L antibody was raised against synthetic peptide (- KLH conjugated) from theN-terminus of Human UBE1L. Remarks: Antigen Modification: N-Terminus

Kreuzreaktivität: Human

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Ube1L is a member of the E1 ubiquitin-activating enzyme family. It is a retinoid target thattriggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradationand apoptosis in acute promyelocytic leukemia. It has been reported that Ube1L acts as theactivating enzyme in the ISG15 conjugation pathway. ISG15 is an ubiquitin-like protein andits transcription is induced by interferon treatment.

Spezifität: This antibody reacts to Ubiquitin-activating Enzyme E1 Homolog (UBE1L). Species Reactivity: Tested: Human.

Anwendungen

Applikationshinweise: Western blot. Immunohistochemistry on Paraffin Sections: 10 µg/ml. This antibody was validated for use in Immunohistochemistry on a panel of 21Formalin-Fixed, Paraffin-Embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody, followed by alkalinephosphatase-streptavidin and chromogen. The stained slides were evaluated by apathologist to confirm staining specificity. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 0.2 mg/ml

Reinigung: Aff - Purified

Buffer: PBS, pH 7.4 containing 0.2% BSA as stabilizer and 0.05% Sodium Azide aspreservative.

Lagerung: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar