MAD2L1 Antikörper (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast)) (AA 1-206)

Details for Product anti-MAD2L1 Antibody No. ABIN395553, Anbieter: Anmelden zum Anzeigen
Antigen
  • cb408
  • zgc:112133
  • MAD2L1
  • mad2
  • XMad2
  • AA673185
  • MAD2
  • HSMAD2
  • MAD2 mitotic arrest deficient-like 1 (yeast)
  • MAD2 mitotic arrest deficient-like 1
  • MAD2L1
  • mad2l1
  • LOC100218172
  • Mad2l1
Epitop
AA 1-206
19
7
7
6
4
4
4
3
3
3
2
2
1
1
1
1
1
1
Reaktivität
Human
120
36
33
9
6
5
4
4
4
3
3
2
2
1
Wirt
Maus
72
33
15
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser MAD2L1 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
102
46
23
22
21
20
13
6
2
1
1
1
1
1
Optionen
Hersteller
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Immunogen MAD2L1 (AAH00356, 1 a.a. ~ 206 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Klon 2E2-1D6
Isotyp IgG2b kappa
Spezifität MAD2L1 (AAH00356, 1 a.a. ~ 206 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Andere Bezeichnung MAD2L1 (MAD2L1 Antibody Abstract)
Hintergrund Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molekulargewicht 23510 DA
Gen-ID 12406
Forschungsgebiet Cell Cycle, Cell Structure
Applikationshinweise Western blot = 1:500-1000
Kommentare

Background: MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-MAD2L1 Antikörper (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast)) (AA 1-206) (ABIN395553) MAD2L1 monoclonal antibody (M01), clone 2E2-1D6 Western Blot analysis of MAD2L1 expre...
Immunohistochemistry (IHC) image for anti-MAD2L1 Antikörper (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast)) (AA 1-206) (ABIN395553) anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 1-206) antibody (Image 2)
Allgemeine Veröffentlichungen Hewitt, Tighe, Santaguida, White, Jones, Musacchio, Green, Taylor: "Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex." in: The Journal of cell biology, Vol. 190, Issue 1, pp. 25-34, 2010 (PubMed).

Guo, Zhang, Yang, Miao, Shi, Yao, Tan, Sun, Zhao, Yu, Liu, Lin: "Functional evaluation of missense variations in the human MAD1L1 and MAD2L1 genes and their impact on susceptibility to lung cancer." in: Journal of medical genetics, Vol. 47, Issue 9, pp. 616-22, 2010 (PubMed).

Gladhaug, Westgaard, Schjølberg, Burum-Auensen, Pomianowska, Clausen: "Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours." in: Histopathology, Vol. 56, Issue 3, pp. 345-55, 2010 (PubMed).

Wang, Yin, Du, Chen, Liang, Zhang, Du, Wu, Ding, Fan: "Depression of MAD2 inhibits apoptosis and increases proliferation and multidrug resistance in gastric cancer cells by regulating the activation of phosphorylated survivin." in: Tumour biology, Vol. 31, Issue 3, pp. 225-32, 2010 (PubMed).

Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, 2010 (PubMed).