Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 1-101) Antikörper

Details zu Produkt Nr. ABIN393677, Anbieter: Anmelden zum Anzeigen
Antigen
  • p40phox
  • AI451400
  • NCF
  • P40PHOX
  • SH3PXD4
  • p40phox protein
  • neutrophil cytosolic factor 4
  • neutrophil cytosolic factor 4, 40kDa
  • p40phox
  • LOC100136241
  • Ncf4
  • NCF4
Epitop
AA 1-101
19
9
9
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
117
58
44
7
7
5
4
4
3
3
Wirt
Maus
91
20
10
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
ELISA
75
40
33
26
23
5
4
3
3
2
2
1
Optionen
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Immunogen NCF4 (AAH02798, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Klon 3C10
Isotyp IgG2a kappa
Spezifität NCF4 (AAH02798, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Andere Bezeichnung NCF4 (NCF4 Antibody Abstract)
Hintergrund Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molekulargewicht 39032 DA
Gen-ID 12406
Forschungsgebiet Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Applikationshinweise ELISA ~~ 1ug/ml~3ng/ml
Kommentare

Background: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer PBS with 0.09% (w/v) sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Bilder des Herstellers
ELISA image for anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (AA 1-101) Antikörper (ABIN393677) Detection limit for recombinant GST tagged NCF4 is approximately 0.3 ng/mL as a captu...
Allgemeine Veröffentlichungen Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Han, Lan, Park, Lee, Park, Ahn, Shin, Kang, Koo, Seo, Choi, Ahn, Chanock, Kim, Rothman, Kang: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta, Pfeiffer, Wang, Yeager, Thomas, Fine, Linet, Rothman, Chanock, Inskip: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Roos, Kuhns, Maddalena, Bustamante, Kannengiesser, de Boer, van Leeuwen, Köker, Wolach, Roesler, Malech, Holland, Gallin, Stasia: "Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update)." in: Blood cells, molecules & diseases, Vol. 44, Issue 4, pp. 291-9, 2010 (PubMed).

Segat, Brandão, Guimarães, Pontillo, Athanasakis, de Oliveira, Arraes, de Lima Filho, Crovella: "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment." in: Vaccine, Vol. 28, Issue 10, pp. 2201-6, 2010 (PubMed).