MAP2K5 Antikörper (Mitogen-Activated Protein Kinase Kinase 5) (Met11)

Details for Product anti-MAP2K5 Antibody No. ABIN393416, Anbieter: Anmelden zum Anzeigen
Antigen
  • Mek5
  • HsT17454
  • MAPKK5
  • MEK5
  • PRKMK5
  • AI324775
  • AI428457
  • Mapkk5
  • Prkmk5
  • fb73f02
  • wu:fb73f02
  • zgc:172137
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
  • ATMAP2K_ALPHA
  • ATMEK5
  • ATMKK5
  • MAP KINASE KINASE 5
  • MAP kinase kinase 5
  • MAP2K_A
  • mitogen activated protein kinase kinase 5
  • mitogen-activated protein kinase kinase 5
  • Map2k5
  • MAP2K5
  • map2k5
  • MKK5
Epitop
Met11
33
32
15
15
15
15
14
11
10
9
6
6
5
4
4
4
3
3
2
2
2
1
1
1
1
1
Reaktivität
Human
169
90
83
11
7
7
6
4
3
3
3
3
2
2
2
2
1
1
Wirt
Maus
165
15
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser MAP2K5 Antikörper ist unkonjugiert
9
9
9
5
5
5
5
5
5
5
5
5
5
4
4
4
4
Applikation
Immunofluorescence (IF), Western Blotting (WB)
112
64
47
28
25
21
4
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Klon 3E10
Isotyp IgG1 kappa
Spezifität MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Andere Bezeichnung MAP2K5 (MAP2K5 Antibody Abstract)
Hintergrund Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molekulargewicht 50112 DA
Gen-ID 12406
Forschungsgebiet Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Pathways MAPK Signalweg, Neurotrophin Signalübertragung
Applikationshinweise Western blot = 1:500-1000
Kommentare

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer PBS with 0.09% (w/v) sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody (ABIN393416) Immunofluorescence of monoclonal antibody to MAP2K5 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody (ABIN393416) anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody (Image 2)
Allgemeine Veröffentlichungen Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Kripke, Shadan, Dawson, Cronin, Jamil, Grizas, Koziol, Kline: "Genotyping sleep disorders patients." in: Psychiatry investigation, Vol. 7, Issue 1, pp. 36-42, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Rivière, Xiong, Levchenko, St-Onge, Gaspar, Dion, Lespérance, Tellier, Richer, Chouinard, Rouleau,: "Association of intronic variants of the BTBD9 gene with Tourette syndrome." in: Archives of neurology, Vol. 66, Issue 10, pp. 1267-72, 2009 (PubMed).

Spiering, Schmolke, Ohnesorge, Schmidt, Goebeler, Wegener, Wixler, Ludwig: "MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24972-80, 2009 (PubMed).

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