SETDB2 Antikörper (SET Domain, Bifurcated 2) (AA 620-720)

Details for Product anti-SETDB2 Antibody No. ABIN393380, Anbieter: Anmelden zum Anzeigen
Antigen
  • C13orf4
  • CLLD8
  • CLLL8
  • KMT1F
  • Clld8
  • Gm293
  • SET domain, bifurcated 2
  • SETDB2
  • Setdb2
Epitop
AA 620-720
28
8
6
3
3
2
1
1
1
1
1
Reaktivität
Human
75
21
18
5
5
4
3
2
1
1
1
Wirt
Maus
29
28
17
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser SETDB2 Antikörper ist unkonjugiert
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
55
42
13
4
3
3
3
2
1
Optionen
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Immunogen SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Klon 1E2
Isotyp IgG2a kappa
Spezifität SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Reinigung Purified
Andere Bezeichnung SETDB2 (SETDB2 Antibody Abstract)
Hintergrund Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
Synonyms: C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217 SET domain, bifurcated 2
Molekulargewicht 81894 DA
Gen-ID 83852
NCBI Accession NP_114121
Forschungsgebiet Signaling, Protein Modifications, Chromatin, Cell Structure
Applikationshinweise Western blot = 1:500-1000
Kommentare

Background: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Phosphate buffered saline, pH 7.2
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-SETDB2 Antikörper (SET Domain, Bifurcated 2) (AA 620-720) (ABIN393380) SETDB2 monoclonal antibody (M07), clone 1E2. Western Blot analysis of SETDB2 expressi...
Allgemeine Veröffentlichungen Falandry, Fourel, Galy, Ristriani, Horard, Bensimon, Salles, Gilson, Magdinier: "CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20234-41, 2010 (PubMed).

Genuneit, Cantelmo, Weinmayr, Wong, Cooper, Riikjärv, Gotua, Kabesch, von Mutius, Forastiere, Crane, Nystad, El-Sharif, Batlles-Garrido, García-Marcos, García-Hernández, Morales-Suarez-Varela, Nilsson, Bråbäck, Saraçlar, Weiland, Cookson, Strachan, Moffat: "A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 39, Issue 12, pp. 1875-88, 2010 (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Dunham, Matthews, Burton, Ashurst, Howe, Ashcroft, Beare, Burford, Hunt, Griffiths-Jones, Jones, Keenan, Oliver, Scott, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey et al.: "The DNA sequence and analysis of human chromosome 13. ..." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).