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SET Domain, Bifurcated 2 (SETDB2) (AA 620-720) Antikörper

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Antigen
Synonyme C13orf4, CLLD8, CLLL8, KMT1F, Clld8, Gm293
Epitop
AA 620-720
(31), (6), (3), (3), (1), (1), (1), (1), (1), (1)
Reaktivität
Human
(62), (19), (16), (6), (5), (5), (1)
Wirt
Maus
(29), (23), (10)
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation
Western Blotting (WB)
(49), (35), (11), (3), (2), (2), (2), (2), (1)
Pubmed 5 Publikationen vorhanden
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Menge 0.05 mg
Optionen
Lieferung nach Deutschland ( )
Verfügbarkeit Lieferung in 12 bis 16 Werktagen
Immunogen SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Klon 1E2
Isotyp IgG2a kappa
Spezifität SETDB2 (NP_114121, 620 a.a. ~ 720 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Reinigung Purified
Andere Bezeichnung SETDB2 (SETDB2 Antibody Abstract)
Hintergrund Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
Synonyms: C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217 SET domain, bifurcated 2
Molekulargewicht 81894 DA
Gen-ID 83852
NCBI Accession NP_114121
Forschungsgebiet Signaling, Protein Modifications, Chromatin, Cell Structure
Pathways
Applikationshinweise Western blot = 1:500-1000
Kommentare

Background: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).

Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Phosphate buffered saline, pH 7.2
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-SET Domain, Bifurcated 2 (SETDB2) (AA 620-720) Antikörper (ABIN393380) SETDB2 monoclonal antibody (M07), clone 1E2. Western Blot analysis of SETDB2 expressi...
Allgemeine Veröffentlichungen Falandry, Fourel, Galy et al.: "CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20234-41, 2010 (PubMed).

Genuneit, Cantelmo, Weinmayr et al.: "A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 39, Issue 12, pp. 1875-88, 2010 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Dunham, Matthews, Burton et al.: "The DNA sequence and analysis of human chromosome 13. ..." in: Nature, Vol. 428, Issue 6982, pp. 522-8, 2004 (PubMed).

Produktnummer ABIN393380
454,76 €
Zzgl. Versandkosten 20,00 € und MWSt

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