Hexokinase 1 Antikörper (N-Term)

Produktnummer ABIN392759

Produktdetails anti-Hexokinase 1 Antikörper

Target: Hexokinase 1 (HK1)

Bindungsspezifität: AA 78-108, N-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Hexokinase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HK1 (Hexokinase) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from the N-terminal region of human HK1 (Hexokinase).

Klon: RB3921-RB3922

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Hexokinase 1 Antikörper (ABIN392759)

Lynn, Wang, Markesbery, Lovell: "Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 19, Issue 1, pp. 325-39, (2010) (PubMed).

Details zu Hexokinase 1

Target: Hexokinase 1 (HK1)

Andere Bezeichnung: HK1 (Hexokinase) (HK1 Produkte)

Synonyme: HK1-ta antikoerper, HK1-tb antikoerper, HK1-tc antikoerper, HKD antikoerper, HKI antikoerper, HMSNR antikoerper, HXK1 antikoerper, Hexokinase antikoerper, hk1 antikoerper, HEX antikoerper, HEX-1 antikoerper, HK antikoerper, ARABIDOPSIS THALIANA HEXOKINASE 1 antikoerper, ATHXK1 antikoerper, F19B15.160 antikoerper, F19B15_160 antikoerper, GIN2 antikoerper, GLUCOSE INSENSITIVE 2 antikoerper, HEXOKINASE antikoerper, hexokinase 1 antikoerper, im:7148527 antikoerper, wu:fc09d08 antikoerper, wu:fc16e02 antikoerper, wu:fc21e02 antikoerper, wu:fq14b11 antikoerper, zgc:55790 antikoerper, zgc:77618 antikoerper, hexokinase-1 antikoerper, HK1 antikoerper, BB404130 antikoerper, Hk-1 antikoerper, Hk1-s antikoerper, dea antikoerper, mHk1-s antikoerper, HEXOKIN antikoerper, Hxk1 antikoerper, NtHxK1 antikoerper, NtHxk antikoerper, hexokinase antikoerper, StHK1 antikoerper, hxk antikoerper, hk1-A antikoerper, hexokinase 1 antikoerper, hexokinase-1 antikoerper, Hexokinase 1 antikoerper, hexokinase 1, putative antikoerper, hexokinase 1 L homeolog antikoerper, HK1 antikoerper, hk1 antikoerper, LOC100136279 antikoerper, Hex1 antikoerper, HXK1 antikoerper, Hk1 antikoerper, TA19800 antikoerper, hxk1 antikoerper, LOC107797523 antikoerper, LOC102604144 antikoerper, hk1.L antikoerper

Hintergrund: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus, the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

Molekulargewicht: 102486

Gen-ID: 3098

NCBI Accession: NP_000179, NP_277031, NP_277032, NP_277033, NP_277035

UniProt: P19367

Pathways: Carbohydrate Homeostasis, Warburg Effekt