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Hexokinase 2 Antikörper (N-Term)

HK2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB3917 unconjugated
Produktnummer ABIN392755
  • Target Alle Hexokinase 2 (HK2) Antikörper anzeigen
    Hexokinase 2 (HK2)
    Bindungsspezifität
    • 15
    • 9
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 91-121, N-Term
    Reaktivität
    • 79
    • 30
    • 24
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 68
    • 20
    Kaninchen
    Klonalität
    • 68
    • 20
    Polyklonal
    Konjugat
    • 53
    • 8
    • 8
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Hexokinase 2 Antikörper ist unkonjugiert
    Applikation
    • 71
    • 38
    • 37
    • 12
    • 12
    • 12
    • 10
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M, Pig, Rat
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HK2 (Hexokinase II) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-121 amino acids from the N-terminal region of human HK2 (Hexokinase II).
    Klon
    RB3917
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product HK2 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Palmieri, Fitzgerald, Shreeve, Hua, Bronder, Weil, Davis, Stark, Merino, Kurek, Mehdorn, Davis, Steinberg, Meltzer, Aldape, Steeg: "Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis." in: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1438-45, (2009) (PubMed).

  • Target
    Hexokinase 2 (HK2)
    Andere Bezeichnung
    HK2 (Hexokinase II) (HK2 Produkte)
    Synonyme
    HKII antikoerper, HXK2 antikoerper, AI642394 antikoerper, hexokinase-2 antikoerper, fi09d05 antikoerper, fi17h06 antikoerper, wu:fi09d05 antikoerper, wu:fi17h06 antikoerper, wu:fi31b04 antikoerper, zgc:55926 antikoerper, HK2 antikoerper, ARABIDOPSIS THALIANA HEXOKINASE 2 antikoerper, ATHXK2 antikoerper, F6F22.11 antikoerper, F6F22_11 antikoerper, HEXOKINASE 2 antikoerper, hexokinase 2 antikoerper, StHK2 antikoerper, hexokinase 2 antikoerper, hexokinase-2 antikoerper, hexokinase 2 L homeolog antikoerper, HK2 antikoerper, Hk2 antikoerper, hk2 antikoerper, HXK2 antikoerper, LOC100032849 antikoerper, hk2.L antikoerper, hxk2 antikoerper, LOC102577690 antikoerper
    Hintergrund
    In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
    Molekulargewicht
    102380
    Gen-ID
    3099
    NCBI Accession
    NP_000180
    UniProt
    P52789
    Pathways
    PI3K-Akt Signalweg, Carbohydrate Homeostasis, Warburg Effekt
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