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PACSIN2 Antikörper (Protein Kinase C and Casein Kinase Substrate in Neurons 2) (AA 342-371)

Details für Produkt anti-PACSIN2 Antikörper Nr. ABIN392666, Anbieter: Anmelden zum Anzeigen
Antigen
  • AI197433
  • DKFZp459J1025
  • PACSIN2
  • SdpII
  • sdpii
  • SDPII
  • zgc:77519
Epitop
AA 342-371, C-Term
17
7
4
3
1
1
1
1
1
Reaktivität
Human, Maus
43
11
7
3
3
2
2
2
1
1
Wirt
Kaninchen
38
5
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser PACSIN2 Antikörper ist unkonjugiert
2
2
2
2
2
2
Applikation
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
38
22
21
9
9
6
1
Hersteller
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Immunogen This PACSIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-371 AA from the C-terminal region of human PACSIN2.
Klon RB3584
Isotyp Ig
Spezifität This PACSIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349~379 amino acids from the C-terminal region of human PACSIN2.
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Andere Bezeichnung PACSIN2 (PACSIN2 Antibody Abstract)
Hintergrund PACSIN may play a role in vesicle formation and transport. This protein homo- and hetero-aggregates with other PACSINs. It also binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). The protein exhibits a cvesicle-like cytoplasmic distribution and is ubiquitously expressed. PACSIN is phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). The protein contains 1 FCH domain and 1 SH3 domain.
Synonyms: Protein kinase C and casein kinase substrate in neurons protein 2
Molekulargewicht 55738 Da
Gen-ID 11252
UniProt Q9UNF0
Forschungsgebiet Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Applikationshinweise IF = 1:100, WB = 1:1000, IHC (p) = 1:50-100
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-PACSIN2 Antikörper (Protein Kinase C and Casein Kinase Substrate in Neurons 2) (AA 342-371) (ABIN392666) The anti-PACSIN2 Pab (ABIN392666) is used in Western blot to detect PACSIN2 in T-47D ...
Immunohistochemistry (IHC) image for anti-PACSIN2 Antikörper (Protein Kinase C and Casein Kinase Substrate in Neurons 2) (AA 342-371) (ABIN392666) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Produkt verwendet in: Cai, Giridharan, Zhang, Saxena, Bahl, Schmidt, Sorgen, Guo, Naslavsky, Caplan: "Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes." in: The Journal of biological chemistry, Vol. 288, Issue 42, pp. 30172-80, 2013

Giridharan, Cai, Vitale, Naslavsky, Caplan: "Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis." in: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1776-90, S1-15, 2013

de Kreuk, Anthony, Geerts, Hordijk: "The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization." in: The Journal of biological chemistry, Vol. 287, Issue 52, pp. 43438-53, 2012

Hansen, Howard, Nichols: "Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis." in: Journal of cell science, Vol. 124, Issue Pt 16, pp. 2777-85, 2011

de Kreuk, Nethe, Fernandez-Borja, Anthony, Hensbergen, Deelder, Plomann, Hordijk: "The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration." in: Journal of cell science, Vol. 124, Issue Pt 14, pp. 2375-88, 2011

Allgemeine Veröffentlichungen Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002

Dunham, Shimizu, Roe, Chissoe, Hunt, Collins, Bruskiewich, Beare, Clamp, Smink, Ainscough, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beasley, Bird, Blakey, Bridgeman, Buck, Burgess, Burrill et al.: "The DNA sequence of human chromosome 22. ..." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999