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PRKG2 Antikörper (C-Term)

PRKG2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB01036 unconjugated
Produktnummer ABIN392537
  • Target Alle PRKG2 Antikörper anzeigen
    PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
    Bindungsspezifität
    • 10
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 714-744, C-Term
    Reaktivität
    • 39
    • 18
    • 17
    • 1
    Human
    Wirt
    • 37
    • 2
    Kaninchen
    Klonalität
    • 38
    • 1
    Polyklonal
    Konjugat
    • 22
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRKG2 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 26
    • 21
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This cGKII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 714-744 amino acids from the C-terminal region of human cGKII.
    Klon
    RB01036
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Zhu, Yao, Wu, Qian, Wu, Chen: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).

    Yao, Wu, Zhu, Qian, Chen et al.: "Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine ..." in: Oncology letters, Vol. 10, Issue 1, pp. 479-484, (2015) (PubMed).

    Jiang, Wu, Wu, Lan, Wang, Qian, Chen: "Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines." in: Oncology letters, Vol. 9, Issue 6, pp. 2781-2786, (2015) (PubMed).

    Rangaswami, Marathe, Zhuang, Chen, Yeh, Frangos, Boss, Pilz: "Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14796-808, (2009) (PubMed).

  • Target
    PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
    Andere Bezeichnung
    cGKII (PRKG2 Produkte)
    Synonyme
    MGC82580 antikoerper, PRKG2 antikoerper, si:dkey-18e17.2 antikoerper, PRKGR2 antikoerper, cGKII antikoerper, GDPKII antikoerper, AW212535 antikoerper, CGKII antikoerper, Prkgr2 antikoerper, cGK-II antikoerper, protein kinase, cGMP-dependent, type II antikoerper, protein kinase, cGMP-dependent, type II L homeolog antikoerper, cGMP-dependent protein kinase 2 antikoerper, PRKG2 antikoerper, prkg2.L antikoerper, prkg2 antikoerper, LOC100541294 antikoerper, Prkg2 antikoerper
    Hintergrund
    CGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50 % of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
    Molekulargewicht
    87432
    Gen-ID
    5593
    NCBI Accession
    NP_006250
    UniProt
    Q13237
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