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MYLK Antikörper (N-Term)

MYLK Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB03067 unconjugated
Produktnummer ABIN392495
  • Target Alle MYLK Antikörper anzeigen
    MYLK (Myosin Light Chain Kinase (MYLK))
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 923-953, N-Term
    Reaktivität
    • 84
    • 41
    • 35
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 92
    • 4
    • 3
    • 1
    Kaninchen
    Klonalität
    • 87
    • 13
    Polyklonal
    Konjugat
    • 42
    • 9
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MYLK Antikörper ist unkonjugiert
    Applikation
    • 44
    • 41
    • 30
    • 13
    • 13
    • 12
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    Rb
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MLCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 923-953 amino acids from the N-terminal region of human MLCK.
    Klon
    RB03067
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MYLK Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
    Haltbarkeit
    6 months
  • Rossi, Todd, Daniels, Bazan, Belayev: "Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice." in: Journal of neurotrauma, (2015) (PubMed).

    Xu, Hu, Liu, Xu, Li, Wu, Shi, Tang: "P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury." in: Molecular neurobiology, (2015) (PubMed).

  • Target
    MYLK (Myosin Light Chain Kinase (MYLK))
    Andere Bezeichnung
    MLCK (MYLK Produkte)
    Synonyme
    AAT7 antikoerper, KRP antikoerper, MLCK antikoerper, MLCK1 antikoerper, MLCK108 antikoerper, MLCK210 antikoerper, MSTP083 antikoerper, MYLK1 antikoerper, smMLCK antikoerper, 9530072E15Rik antikoerper, A930019C19Rik antikoerper, AW489456 antikoerper, Mlck antikoerper, SMMLCK antikoerper, mlck antikoerper, fj60a06 antikoerper, mlck1a antikoerper, mylk antikoerper, wu:fj60a06 antikoerper, zmlck1 antikoerper, myosin light chain kinase antikoerper, myosin, light polypeptide kinase antikoerper, myosin, light chain kinase a antikoerper, MYLK antikoerper, Mylk antikoerper, mylka antikoerper
    Hintergrund
    MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.
    Molekulargewicht
    210715
    NCBI Accession
    NP_444253, NP_444254, NP_444255, NP_444256, NP_444259, NP_444260
    UniProt
    Q15746
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