EPHA1 Antikörper (C-Term)

Produktnummer ABIN391884

Produktdetails anti-EPHA1 Antikörper

Target: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Bindungsspezifität: AA 913-943, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPHA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This EphA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 913-943 amino acids from the C-terminal region of human EphA1.

Klon: RB1578

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-EPHA1 Antikörper (ABIN391884)

Wang, Hu, Tian, Zhou, Zhou, Wang: "Expression of EphA2 protein is positively associated with age, tumor size and Fuhrman nuclear grade in clear cell renal cell carcinomas." in: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 13374-80, (2016) (PubMed).

Wang, Liu, Cao, Zhang, Xu, Xu, Wang: "Expression of the EphA1 protein is associated with Fuhrman nuclear grade in clear cell renal cell carcinomas." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6821-7, (2015) (PubMed).

Dong, Wang, Sheng, Li, Ma, Wang, Zhang, Lu, Hu, Sugimura, Zhou: "Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 1, pp. 151-60, (2008) (PubMed).

Details zu EPHA1

Target: EPHA1 (Ephrin Type A Receptor 1 (EPHA1))

Andere Bezeichnung: EphA1 (EPHA1 Produkte)

Synonyme: EPH antikoerper, EPHT antikoerper, EPHT1 antikoerper, 5730453L17Rik antikoerper, AL033318 antikoerper, Eph antikoerper, Esk antikoerper, EPHA9 antikoerper, EPH receptor A1 antikoerper, Eph receptor A1 antikoerper, EPHA1 antikoerper, Epha1 antikoerper

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molekulargewicht: 108127

Gen-ID: 2041

NCBI Accession: NP_005223

UniProt: P21709