ADAMTS4 Antikörper (C-Term)

Produktnummer ABIN391642

Produktdetails anti-ADAMTS4 Antikörper

Target: ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Bindungsspezifität: AA 705-736, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAMTS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 amino acids from the C-terminal region of human ADAMTS4.

Klon: RB18037

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ADAMTS4 Antikörper (ABIN391642)

Lee, Lee, Gil, Kim, Lee, Kim, Park: "Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases." in: Archives of pathology & laboratory medicine, Vol. 138, Issue 5, pp. 643-50, (2014) (PubMed).

Details zu ADAMTS4

Target: ADAMTS4 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4))

Andere Bezeichnung: ADAMTS4 (ADAMTS4 Produkte)

Synonyme: 3830423K05 antikoerper, ADAM-TS4 antikoerper, ADAMTS-2 antikoerper, ADMP-1 antikoerper, mKIAA0688 antikoerper, ADAMTS-4 antikoerper, ADAMTS4 antikoerper, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 antikoerper, ADAM metallopeptidase with thrombospondin type 1 motif 4 antikoerper, ADAM metallopeptidase with thrombospondin type 1 motif, 4 antikoerper, Adamts4 antikoerper, ADAMTS4 antikoerper

Hintergrund: ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Molekulargewicht: 90197

Gen-ID: 9507

NCBI Accession: NP_005090

UniProt: O75173