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MGMT Antikörper (C-Term)

MGMT Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB19082 unconjugated
Produktnummer ABIN391514
  • Target Alle MGMT Antikörper anzeigen
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    Bindungsspezifität
    • 17
    • 13
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 156-182, C-Term
    Reaktivität
    • 74
    • 19
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 69
    • 12
    Kaninchen
    Klonalität
    • 61
    • 20
    Polyklonal
    Konjugat
    • 46
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser MGMT Antikörper ist unkonjugiert
    Applikation
    • 56
    • 33
    • 22
    • 22
    • 13
    • 13
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MGMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-182 amino acids from the C-terminal region of human MGMT.
    Klon
    RB19082
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MGMT Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Ge, Guo, Zhang, Lin, Li, Liu, Kong, Fang, Zhao: "Impact of O6-methylguanine-DNA methyltransferase expression on the drug resistance of clear cell renal cell carcinoma." in: Japanese journal of clinical oncology, (2015) (PubMed).

    Wu, Cai, Lin, Xiong, Lu, Mao, Yao, Zhou: "High-mobility group box 2 is associated with prognosis of glioblastoma by promoting cell viability, invasion, and chemotherapeutic resistance." in: Neuro-oncology, Vol. 15, Issue 9, pp. 1264-75, (2013) (PubMed).

  • Target
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    Andere Bezeichnung
    MGMT (MGMT Produkte)
    Synonyme
    AGT antikoerper, AI267024 antikoerper, Agat antikoerper, O-6-methylguanine-DNA methyltransferase antikoerper, MGMT antikoerper, Mgmt antikoerper
    Hintergrund
    MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. This protein repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the protein is irreversibly inactivated.
    Molekulargewicht
    21646
    Gen-ID
    4255
    UniProt
    P16455
    Pathways
    DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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