p38 Antikörper (MAP kinase p38) (AA 301-330)

Details for Product anti-p38 Antibody No. ABIN391332, Anbieter: Anmelden zum Anzeigen
Antigen
  • CSBP
  • CSBP1
  • CSBP2
  • CSPB1
  • EXIP
  • Mxi2
  • PRKM14
  • PRKM15
  • RK
  • SAPK2A
  • p38
  • p38ALPHA
  • mitogen-activated protein kinase 14
  • MAPK14
Alternativen
anti-Maus p38 Antikörper für Antibody Array
Epitop
AA 301-330, Tyr323
80
63
33
20
15
15
12
10
9
8
8
6
5
4
4
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
367
265
263
48
30
29
28
26
26
25
21
21
15
15
12
7
5
3
2
1
1
1
Wirt
Kaninchen
276
94
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser p38 Antikörper ist unkonjugiert
10
10
9
7
7
7
6
5
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Western Blotting (WB)
305
159
153
94
67
55
46
28
28
18
13
10
7
6
6
2
1
1
1
1
1
Optionen
Hersteller
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Immunogen This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-330 AA from human MAPK14.
Klon RB13245
Isotyp Ig
Spezifität This MAPK14 (p38) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y323 of human MAPK14.
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung MAPK14 (p38) (p38 Antibody Abstract)
Hintergrund MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Synonyms: Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38alpha, MAP kinase p38alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
Molekulargewicht 41293 DA
Gen-ID 1432
UniProt Q16539
Forschungsgebiet Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling
Applikationshinweise WB = 1:1000, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.28 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-p38 Antikörper (MAP kinase p38) (AA 301-330) (ABIN391332) Western blot analysis of MAPK14 Antibody (Y322) (ABIN391332) in HepG2 cell line lysat...
Western Blotting (WB) image for anti-p38 Antikörper (MAP kinase p38) (AA 301-330) (ABIN391332) Western blot analysis of MAPK14(arrow) using rabbit polyclonal MAPK14 Antibody (Y322)...
Allgemeine Veröffentlichungen Cheung, Campbell, Nebreda, Cohen: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003 (PubMed).

Dean, Sarsfield, Tsounakou, Saklatvala: "p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39470-6, 2003 (PubMed).