VDAC1 Antikörper (N-Term)

Produktnummer ABIN390563

Produktdetails anti-VDAC1 Antikörper

Target: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VDAC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Homologie: B, Pig, Rb, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human VDAC1.

Klon: RB19920

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:8000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-VDAC1 Antikörper (ABIN390563)

Chu, Goldman, Kelly, He, Waliczek, Kordower: "Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease." in: Neurobiology of disease, Vol. 69, pp. 1-14, (2014) (PubMed).

Details zu VDAC1

Target: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Andere Bezeichnung: VDAC1 (VDAC1 Produkte)

Synonyme: vdac1 antikoerper, VDAC1 antikoerper, 5076 antikoerper, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1 antikoerper, ATVDAC1 antikoerper, T22N4.9 antikoerper, T22N4_9 antikoerper, voltage dependent anion channel 1 antikoerper, PORIN antikoerper, VDAC-1 antikoerper, AL033343 antikoerper, Vdac5 antikoerper, fa13f11 antikoerper, wu:fa13f11 antikoerper, zgc:85830 antikoerper, voltage-dependent anion channel 1 S homeolog antikoerper, voltage-dependent anion channel 1 antikoerper, voltage dependent anion channel 1 antikoerper, vdac1.S antikoerper, vdac1 antikoerper, VDAC1 antikoerper, Vdac1 antikoerper

Hintergrund: VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Molekulargewicht: 30773

Gen-ID: 7416

NCBI Accession: NP_003365

UniProt: P21796