Caspase 8 Antikörper (Caspase 8, Apoptosis-Related Cysteine Peptidase) (AA 432-461)

Details for Product anti-CASP8 Antibody No. ABIN390474, Anbieter: Anmelden zum Anzeigen
Antigen
  • casp8-A
  • xCaspase-8
  • casp8
  • CASP8
  • CASP-8
  • FLICE
  • MACH
  • Mch5
  • ALPS2B
  • CAP4
  • Casp-8
  • MCH5
  • caspase-8
  • zgc:92075
  • caspase 8, apoptosis-related cysteine peptidase
  • death related ced-3/Nedd2-like protein
  • caspase-8
  • caspase 8
  • casp8
  • Dredd
  • CASP8
  • AaeL_AAEL014148
  • LOC100222284
  • Casp8
  • LOC100348477
Alternativen
anti-Human Caspase 8 Antikörper für Cellular Assay
Epitop
AA 432-461, C-Term
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Reaktivität
Human
353
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25
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20
3
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Wirt
Kaninchen
270
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Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser Caspase 8 Antikörper ist unkonjugiert
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Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Optionen
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Immunogen This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 AA from the C-terminal region of human CASP8.
Klon RB18993
Isotyp Ig
Spezifität This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 439~469 amino acids from the C-terminal region of human CASP8.
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Andere Bezeichnung CASP8 (CASP8 Antibody Abstract)
Hintergrund CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.
Synonyms: Caspase-8, CASP-8, ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p1
Molekulargewicht 55391 Da
Gen-ID 841
UniProt Q14790
Forschungsgebiet Apoptosis/Necrosis
Pathways Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
Applikationshinweise WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50, IF = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Caspase 8 Antikörper (Caspase 8, Apoptosis-Related Cysteine Peptidase) (AA 432-461) (ABIN390474) Western blot analysis of CASP8 antibody (C-term) (ABIN390474) in Hela cell line lysat...
Immunohistochemistry (IHC) image for anti-Caspase 8 Antikörper (Caspase 8, Apoptosis-Related Cysteine Peptidase) (AA 432-461) (ABIN390474) Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CASP8 Antibod...
Flow Cytometry (FACS) image for anti-Caspase 8 Antikörper (Caspase 8, Apoptosis-Related Cysteine Peptidase) (AA 432-461) (ABIN390474) Flow cytometric analysis of hela cells using CASP8 Antibody (C-term)(bottom histogram...
Produkt verwendet in: Lin, Huang, Lin, Lin: "p-Cresol mediates autophagic cell death in renal proximal tubular cells." in: Toxicology letters, Vol. 234, Issue 1, pp. 20-9, 2015 (PubMed).

Allgemeine Veröffentlichungen Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: "Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality." in: Human reproduction (Oxford, England), Vol. 24, Issue 10, pp. 2439-46, 2009 (PubMed).