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SIRT6 Antikörper (C-Term)

SIRT6 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB2109 unconjugated
Produktnummer ABIN390181
  • Target Alle SIRT6 Antikörper anzeigen
    SIRT6 (Sirtuin 6 (SIRT6))
    Bindungsspezifität
    • 15
    • 15
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 290-319, C-Term
    Reaktivität
    • 91
    • 30
    • 16
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 87
    • 12
    • 2
    Kaninchen
    Klonalität
    • 82
    • 19
    Polyklonal
    Konjugat
    • 52
    • 12
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIRT6 Antikörper ist unkonjugiert
    Applikation
    • 82
    • 40
    • 36
    • 14
    • 14
    • 11
    • 7
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This SIRT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from the C-terminal region of human SIRT6.
    Klon
    RB2109
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SIRT6 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:500. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Haltbarkeit
    6 months
  • Li, Shi, Yang, Yan, Zhang, Yang, He, Li, Yi, Sun, Liang, Cheng, Shi, Shang, Yu: "SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability." in: Nature communications, Vol. 7, pp. 12235, (2018) (PubMed).

    Wang, Zhang, Liang, Zhang, Xu, Zhang, Fuji, Mu, Li, Jiang, Ju, Wang: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." in: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).

    Wu, Liu, Fu, Liu, Zhou: "Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients." in: Annals of clinical and laboratory science, Vol. 44, Issue 4, pp. 410-8, (2014) (PubMed).

    Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." in: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

  • Target
    SIRT6 (Sirtuin 6 (SIRT6))
    Andere Bezeichnung
    SIRT6 (SIRT6 Produkte)
    Synonyme
    2810449N18Rik antikoerper, AI043036 antikoerper, Sir2l6 antikoerper, SIR2L6 antikoerper, zgc:86729 antikoerper, sirtuin 6 antikoerper, sirtuin 6 S homeolog antikoerper, Sirt6 antikoerper, SIRT6 antikoerper, sirt6.S antikoerper, sirt6 antikoerper
    Hintergrund
    SIRT6 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
    Molekulargewicht
    39119
    Gen-ID
    51548
    NCBI Accession
    NP_001180214, NP_057623
    UniProt
    Q8N6T7
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