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SIRT3 Antikörper (C-Term)

SIRT3 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB01967 unconjugated
Produktnummer ABIN390178
  • Target Alle SIRT3 Antikörper anzeigen
    SIRT3 (Sirtuin 3 (SIRT3))
    Bindungsspezifität
    • 16
    • 10
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 250-279, C-Term
    Reaktivität
    • 95
    • 43
    • 19
    • 9
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Human, Maus
    Wirt
    • 86
    • 16
    • 2
    • 2
    • 2
    Kaninchen
    Klonalität
    • 93
    • 16
    Polyklonal
    Konjugat
    • 60
    • 15
    • 12
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIRT3 Antikörper ist unkonjugiert
    Applikation
    • 95
    • 64
    • 43
    • 10
    • 8
    • 8
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SIRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human SIRT3.
    Klon
    RB01967
    Isotyp
    IgG
  • Applikationshinweise
    WB: 1:2000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Haltbarkeit
    6 months
  • Schwab, Sison, Meade, Broniowska, Corbett, Ebert: "Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons." in: Stem cell reports, Vol. 9, Issue 6, pp. 1839-1852, (2018) (PubMed).

    Takumida, Takumida, Katagiri, Anniko: "Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." in: Acta oto-laryngologica, pp. 1-12, (2015) (PubMed).

    He, Hu, Shi, Weidert, Lu, Xu, Huang, Kelley, Xie: "Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3." in: Molecular and cellular biology, Vol. 33, Issue 10, pp. 2047-55, (2013) (PubMed).

    Kamarajan, Alhazzazi, Danciu, Dsilva, Verdin, Kapila: "Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis." in: Cancer, Vol. 118, Issue 23, pp. 5800-10, (2012) (PubMed).

    Parker, Vazquez-Manrique, Tourette, Farina, Offner, Mukhopadhyay, Orfila, Darbois, Menet, Tissenbaum, Neri: "Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 36, pp. 12630-40, (2012) (PubMed).

    Caton, Holness, Bishop-Bailey, Sugden: "PPAR?-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status." in: The Biochemical journal, Vol. 437, Issue 3, pp. 521-30, (2011) (PubMed).

    Xiong, Salazar, Patrushev, Alexander: "FoxO1 mediates an autofeedback loop regulating SIRT1 expression." in: The Journal of biological chemistry, Vol. 286, Issue 7, pp. 5289-99, (2011) (PubMed).

    Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." in: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

    Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: "Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 3133-44, (2010) (PubMed).

    Sundaresan, Gupta, Kim, Rajamohan, Isbatan, Gupta: "Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice." in: The Journal of clinical investigation, Vol. 119, Issue 9, pp. 2758-71, (2009) (PubMed).

    Sundaresan, Samant, Pillai, Rajamohan, Gupta: "SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70." in: Molecular and cellular biology, Vol. 28, Issue 20, pp. 6384-401, (2008) (PubMed).

  • Target
    SIRT3 (Sirtuin 3 (SIRT3))
    Andere Bezeichnung
    SIRT3 (SIRT3 Produkte)
    Synonyme
    zgc:158774 antikoerper, sirtuin antikoerper, SIR2L3 antikoerper, 2310003L23Rik antikoerper, AI848213 antikoerper, Sir2l3 antikoerper, sirtuin 3 antikoerper, sirt3 antikoerper, SIRT3 antikoerper, Sirt3 antikoerper
    Hintergrund
    SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.
    Molekulargewicht
    43573
    Gen-ID
    23410
    NCBI Accession
    NP_001017524, NP_036371
    UniProt
    Q9NTG7
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