ZMIZ1 Antikörper (C-Term)

Produktnummer ABIN390174

Produktdetails anti-ZMIZ1 Antikörper

Target: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Bindungsspezifität: AA 1038-1067, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZMIZ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RAI17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human RAI17.

Klon: RB1963

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ZMIZ1 Antikörper (ABIN390174)

Lan, Lan, Chang, Zhang, Liu, Vikash, Wang, Huang, Wang, Zhou, Chen, Zhao: "Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 41, Issue 5, pp. 2077-2090, (2017) (PubMed).

Pinnell, Yan, Cho, Keeley, Murai, Liu, Alarcon, Qin, Wang, Kuick, Elenitoba-Johnson, Maillard, Samuelson, Cierpicki, Chiang: "The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia." in: Immunity, Vol. 43, Issue 5, pp. 870-83, (2015) (PubMed).

Rakowski, Garagiola, Li, Decker, Caruso, Jones, Kuick, Cierpicki, Maillard, Chiang: "Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias." in: Cancer research, Vol. 73, Issue 2, pp. 930-41, (2013) (PubMed).

Details zu ZMIZ1

Target: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Andere Bezeichnung: RAI17 (ZMIZ1 Produkte)

Synonyme: miz antikoerper, rai17 antikoerper, zimz1 antikoerper, zimp10 antikoerper, hzimp10 antikoerper, MIZ antikoerper, RAI17 antikoerper, TRAFIP10 antikoerper, ZIMP10 antikoerper, hZIMP10 antikoerper, BC065120 antikoerper, E330020C23 antikoerper, ENSMUSG00000072684 antikoerper, Gm10397 antikoerper, I920194n01 antikoerper, Rai17 antikoerper, Zimp10 antikoerper, wu:fb80e10 antikoerper, zgc:175159 antikoerper, zmiz1 antikoerper, zinc finger MIZ-type containing 1 antikoerper, zinc finger, MIZ-type containing 1 antikoerper, zinc finger, MIZ-type containing 1a antikoerper, ZMIZ1 antikoerper, zmiz1 antikoerper, Zmiz1 antikoerper, zmiz1a antikoerper

Hintergrund: Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.

Molekulargewicht: 115483

Gen-ID: 57178

NCBI Accession: NP_065071

UniProt: Q9ULJ6