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MMP12 Antikörper (C-Term)

MMP12 Reaktivität: Human, Maus WB, IHC (p), IF Wirt: Kaninchen Polyclonal RB2026 unconjugated
Produktnummer ABIN390136
  • Target Alle MMP12 Antikörper anzeigen
    MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
    Bindungsspezifität
    • 10
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 391-420, C-Term
    Reaktivität
    • 71
    • 35
    • 34
    • 4
    • 1
    Human, Maus
    Wirt
    • 89
    • 3
    • 2
    • 1
    Kaninchen
    Klonalität
    • 80
    • 15
    Polyklonal
    Konjugat
    • 40
    • 17
    • 13
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MMP12 Antikörper ist unkonjugiert
    Applikation
    • 84
    • 36
    • 34
    • 12
    • 11
    • 11
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MMP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12.
    Klon
    RB2026
    Isotyp
    Ig Fraction
  • Applikationshinweise
    IF: 1:10~50. WB: 1:2000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Du, Wang, Tan, Li, Huang, Huang, Yang, Zhang, Wang, Huang, Huang: "Nkx2-5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E-Deficient Mice." in: Journal of the American Heart Association, Vol. 5, Issue 12, (2017) (PubMed).

    LaPan, Brady, Grierson, Fleming, Miller, Sypek, Fu: "Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum." in: BMC pulmonary medicine, Vol. 10, pp. 40, (2010) (PubMed).

    Ma, Flanc, Tesch, Bennett, Friedman, Nikolic-Paterson: "Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 89, Issue 4, pp. 470-84, (2009) (PubMed).

  • Target
    MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
    Andere Bezeichnung
    MMP12 (MMP12 Produkte)
    Synonyme
    MMP12 antikoerper, AV378681 antikoerper, Mmel antikoerper, Mme antikoerper, HME antikoerper, ME antikoerper, MME antikoerper, MMP-12 antikoerper, matrix metallopeptidase 12 antikoerper, MMP12 antikoerper, Mmp12 antikoerper
    Hintergrund
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.
    Molekulargewicht
    54002
    Gen-ID
    4321
    NCBI Accession
    NP_002417
    UniProt
    P39900
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