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MAGEA3 Antikörper (C-Term)

MAGEA3 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB2084 unconjugated
Produktnummer ABIN390107
  • Target Alle MAGEA3 Antikörper anzeigen
    MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))
    Bindungsspezifität
    • 9
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 283-314, C-Term
    Reaktivität
    • 46
    • 1
    • 1
    Human
    Wirt
    • 33
    • 12
    • 1
    Kaninchen
    Klonalität
    • 34
    • 11
    • 1
    Polyklonal
    Konjugat
    • 26
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAGEA3 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 24
    • 21
    • 15
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 amino acids from the C-terminal region of human MAGEA3.
    Klon
    RB2084
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Curioni-Fontecedro, Knights, Tinguely, Nuber, Schneider, Thomson, von Boehmer, Bossart, Pahlich, Gehring, Moch, Renner, Knuth, Zippelius: "MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma." in: Leukemia, Vol. 22, Issue 8, pp. 1646-8, (2008) (PubMed).

    Dubovsky, Albertini, McNeel: "MAD-CT-2 identified as a novel melanoma cancer-testis antigen using phage immunoblot analysis." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 30, Issue 7, pp. 675-83, (2007) (PubMed).

    Kondo, Zhu, Asa, Ezzat: "The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4713-20, (2007) (PubMed).

  • Target
    MAGEA3 (Melanoma Antigen Family A, 3 (MAGEA3))
    Andere Bezeichnung
    MAGEA3 (MAGEA3 Produkte)
    Synonyme
    CT1.3 antikoerper, HIP8 antikoerper, HYPD antikoerper, MAGE3 antikoerper, MAGEA6 antikoerper, Mage-a3 antikoerper, MAGEA3 antikoerper, MAGE family member A3 antikoerper, melanoma antigen, family A, 3 antikoerper, melanoma antigen family A, 3 antikoerper, MAGEA3 antikoerper, Magea3 antikoerper
    Hintergrund
    MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80 % sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
    Molekulargewicht
    34747
    Gen-ID
    4102
    NCBI Accession
    NP_005353
    UniProt
    P43357
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