Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Ye, Go, Singh, Liu, Keramati, Mani: "LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1335-44, (2012) (PubMed).
Keramati, Singh, Lin, Faramarzi, Ye, Mane, Tellides, Lifton, Mani: "Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 1914-8, (2011) (PubMed).
Liu, Prior, Piwnica-Worms, Bu: "LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 11, pp. 5136-41, (2010) (PubMed).
Target
LRP6
(Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
lrp6-A antikoerper, Xlrp6 antikoerper, adcad2 antikoerper, lrp6 antikoerper, LRP6 antikoerper, ADCAD2 antikoerper, C030016K15Rik antikoerper, Cd antikoerper, Gw antikoerper, LDL receptor related protein 6 antikoerper, LDL receptor related protein 6 L homeolog antikoerper, LDL receptor related protein 6 S homeolog antikoerper, low density lipoprotein receptor-related protein 6 antikoerper, low-density lipoprotein receptor-related protein 6 antikoerper, LRP6 antikoerper, lrp6.L antikoerper, lrp6.S antikoerper, lrp6 antikoerper, Lrp6 antikoerper, LOC590395 antikoerper
Hintergrund
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.