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ATM Antikörper (pSer1981)

ATM Reaktivität: Human IF, DB Wirt: Kaninchen Polyclonal RB8121 unconjugated
Produktnummer ABIN389888
  • Target Alle ATM Antikörper anzeigen
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Bindungsspezifität
    • 32
    • 16
    • 15
    • 13
    • 9
    • 9
    • 8
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer1981
    Reaktivität
    • 162
    • 84
    • 34
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    • 138
    • 24
    • 6
    • 2
    Kaninchen
    Klonalität
    • 132
    • 38
    Polyklonal
    Konjugat
    • 81
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Dieser ATM Antikörper ist unkonjugiert
    Applikation
    • 74
    • 50
    • 39
    • 37
    • 28
    • 26
    • 22
    • 22
    • 18
    • 13
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Dot Blot (DB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Phospho-ATM-pS1981 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.
    Klon
    RB8121
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ATM Primärantikörper
  • Applikationshinweise
    IF: 1:10~50. DB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Matsuda, Sanpei, Wakai, Kubota, Osawa, Hirose, Sakata, Kobayashi, Fujimaki, Takamura, Yamagiwa, Yano, Ohkoshi, Aoyagi: "Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase." in: International journal of clinical and experimental pathology, Vol. 7, Issue 5, pp. 2032-43, (2015) (PubMed).

  • Target
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Andere Bezeichnung
    ATM (ATM Produkte)
    Synonyme
    ATM antikoerper, Atm antikoerper, CG6535 antikoerper, Dmel\\CG6535 antikoerper, Tefu antikoerper, atm antikoerper, atm/tefu antikoerper, dATM antikoerper, tef antikoerper, Xatm antikoerper, at1 antikoerper, atdc antikoerper, tel1 antikoerper, telo1 antikoerper, AT1 antikoerper, ATA antikoerper, ATC antikoerper, ATD antikoerper, ATDC antikoerper, ATE antikoerper, TEL1 antikoerper, TELO1 antikoerper, AI256621 antikoerper, C030026E19Rik antikoerper, telomere fusion antikoerper, ATM serine/threonine kinase L homeolog antikoerper, ATM serine/threonine kinase antikoerper, ataxia telangiectasia mutated antikoerper, ataxia telangiectasia mutated (atm) antikoerper, serine/threonine-protein kinase ATM antikoerper, tefu antikoerper, atm.L antikoerper, atm antikoerper, ATM antikoerper, EDI_100660 antikoerper, CpipJ_CPIJ001772 antikoerper, BDBG_08252 antikoerper, PAAG_02532 antikoerper, MCYG_05088 antikoerper, VDBG_06833 antikoerper, ACLA_015700 antikoerper, LOC5565620 antikoerper, MGYG_07634 antikoerper, PGTG_14279 antikoerper, Atm antikoerper
    Hintergrund
    ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.
    Molekulargewicht
    350687
    Gen-ID
    472
    NCBI Accession
    NP_000042
    UniProt
    Q13315
    Pathways
    p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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