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MAP4K1 Antikörper (pSer171)

MAP4K1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB12751 unconjugated
Produktnummer ABIN389836
  • Target Alle MAP4K1 Antikörper anzeigen
    MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1))
    Bindungsspezifität
    • 16
    • 10
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer171
    Reaktivität
    • 61
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 56
    • 4
    • 1
    Kaninchen
    Klonalität
    • 58
    • 3
    Polyklonal
    Konjugat
    • 31
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAP4K1 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 33
    • 15
    • 14
    • 14
    • 14
    • 8
    • 8
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MAP4K1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1.
    Klon
    RB12751
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MAP4K1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1))
    Andere Bezeichnung
    MAP4K1 (MAP4K1 Produkte)
    Synonyme
    HPK1 antikoerper, Hpk1 antikoerper, mHPK1 antikoerper, mitogen activated protein kinase kinase kinase kinase 1 antikoerper, mitogen-activated protein kinase kinase kinase kinase 1 antikoerper, Map4k1 antikoerper, MAP4K1 antikoerper
    Hintergrund
    The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.
    Molekulargewicht
    91296
    Gen-ID
    11184
    NCBI Accession
    NP_001036065, NP_009112
    UniProt
    Q92918
    Pathways
    T-Zell Rezeptor Signalweg, Signaling of Hepatocyte Growth Factor Receptor
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