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RAF1 Antikörper (pSer259)

RAF1 Reaktivität: Human DB Wirt: Kaninchen Polyclonal RB11131 unconjugated
Produktnummer ABIN389828
  • Target Alle RAF1 Antikörper anzeigen
    RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
    Bindungsspezifität
    • 48
    • 43
    • 35
    • 34
    • 32
    • 27
    • 24
    • 23
    • 23
    • 22
    • 19
    • 18
    • 15
    • 13
    • 13
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer259
    Reaktivität
    • 447
    • 231
    • 159
    • 14
    • 13
    • 12
    • 12
    • 9
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 478
    • 15
    • 2
    • 2
    Kaninchen
    Klonalität
    • 453
    • 44
    Polyklonal
    Konjugat
    • 202
    • 37
    • 28
    • 27
    • 20
    • 20
    • 20
    • 20
    • 20
    • 20
    • 17
    • 16
    • 10
    • 10
    • 10
    • 10
    • 10
    Dieser RAF1 Antikörper ist unkonjugiert
    Applikation
    • 298
    • 217
    • 105
    • 104
    • 89
    • 74
    • 49
    • 31
    • 30
    • 24
    • 16
    • 11
    • 10
    • 3
    • 2
    • 2
    • 1
    Dot Blot (DB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Phospho-RAF1-S259 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S259 of human RAF1.
    Klon
    RB11131
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product RAF1 Primärantikörper
  • Applikationshinweise
    DB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Duan, Cobb: "Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 51, pp. 22314-9, (2010) (PubMed).

  • Target
    RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
    Andere Bezeichnung
    RAF1 (RAF1 Produkte)
    Synonyme
    CRAF antikoerper, NS5 antikoerper, Raf-1 antikoerper, c-Raf antikoerper, c-raf antikoerper, craf antikoerper, raf1 antikoerper, RAF1 antikoerper, 6430402F14Rik antikoerper, AA990557 antikoerper, BB129353 antikoerper, Craf1 antikoerper, D830050J10Rik antikoerper, v-Raf antikoerper, raf antikoerper, cRaf antikoerper, Raf-1 proto-oncogene, serine/threonine kinase antikoerper, Raf-1 proto-oncogene, serine/threonine kinase a antikoerper, v-raf-leukemia viral oncogene 1 antikoerper, Raf-1 proto-oncogene, serine/threonine kinase S homeolog antikoerper, RAF1 antikoerper, Raf1 antikoerper, raf1a antikoerper, raf1 antikoerper, raf1.S antikoerper
    Hintergrund
    Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
    Molekulargewicht
    73052
    Gen-ID
    5894
    NCBI Accession
    NP_002871
    UniProt
    P04049
    Pathways
    MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling, BCR Signaling
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