LC3C Antikörper (pSer12)

Produktnummer ABIN389699

Produktdetails anti-LC3C Antikörper

Target: LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))

Bindungsspezifität: pSer12

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LC3C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Dot Blot (DB)

Homologie: Zf, B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LC3C Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of human LC3C.

Klon: RB10838-RB16769

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-LC3C Antikörper (ABIN389699)

Tanaka, Koyama, Sakurai, Kamiyoshi, Ichikawa-Shindo, Kawate, Liu, Xian, Imai, Zhai, Hirabayashi, Owa, Yamauchi, Igarashi, Taniguchi, Shindo: "The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis." in: Cardiovascular research, Vol. 111, Issue 4, pp. 398-409, (2017) (PubMed).

Xie, Kang, Tang: "Assessment of Posttranslational Modifications of ATG proteins." in: Methods in enzymology, Vol. 587, pp. 171-188, (2017) (PubMed).

Li, Liu, Wang, Wang, Zhao, Su, Zhang, Zhang, Xu, Zhao, Miao: "Identification of a small molecule targeting annexin A7." in: Biochimica et biophysica acta, Vol. 1833, Issue 9, pp. 2092-9, (2013) (PubMed).

Colecchia, Strambi, Sanzone, Iavarone, Rossi, DallArmi, Piccioni, Verrotti di Pianella, Chiariello: "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins." in: Autophagy, Vol. 8, Issue 12, pp. 1724-40, (2012) (PubMed).

Su, Chao, Huang, Weng, Jeng, Lai: "Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy." in: Journal of virology, Vol. 85, Issue 20, pp. 10561-71, (2011) (PubMed).

Cherra, Kulich, Uechi, Balasubramani, Mountzouris, Day, Chu: "Regulation of the autophagy protein LC3 by phosphorylation." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 533-9, (2010) (PubMed).

Details zu LC3C

Target: LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))

Andere Bezeichnung: LC3C (MAP1LC3C Produkte)

Synonyme: MAP1LC3C antikoerper, MGC154878 antikoerper, ATG8J antikoerper, LC3C antikoerper, microtubule associated protein 1 light chain 3 gamma antikoerper, microtubule associated protein 1 light chain 3 gamma L homeolog antikoerper, MAP1LC3C antikoerper, map1lc3c antikoerper, map1lc3c.L antikoerper

Hintergrund: MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

Molekulargewicht: 14272

Gen-ID: 84557

NCBI Accession: NP_115903, NP_852610

UniProt: Q9H492

Pathways: Autophagie