APP Antikörper (Amyloid beta (A4) Precursor Protein) (pSer730)

Details for Product anti-APP Antibody No. ABIN389515, Anbieter: Anmelden zum Anzeigen
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Epitop
pSer730
107
107
72
39
36
32
31
19
17
15
15
14
14
13
12
10
9
7
7
7
7
7
6
6
5
5
5
5
5
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
944
388
369
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Wirt
Kaninchen
657
263
52
7
2
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser APP Antikörper ist unkonjugiert
51
43
41
17
15
14
14
14
13
13
13
13
13
13
13
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
672
403
297
165
159
122
90
57
40
35
17
15
15
10
8
3
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This APP Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP.
Klon RB6972
Isotyp Ig
Spezifität This Phospho-APP-S730 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP.
Homologie Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: Amyloid beta A4 protein [Precursor], APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4, APP, A4, AD1,
Molekulargewicht 86943 DA
Gen-ID 351
UniProt P05067
Forschungsgebiet Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise WB = 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.33 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (pSer730) antibody (ABIN389515) The anti-Phospho-APP-S730 Pab (ABIN389515) is used in Western blot to detect Phospho-...
Allgemeine Veröffentlichungen Borroni, Colciaghi, Caltagirone, Rozzini, Broglio, Cattabeni, Di Luca, Padovani: "Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study." in: Archives of neurology, Vol. 60, Issue 12, pp. 1740-4, 2003 (PubMed).

Lleó, Berezovska, Ramdya, Fukumoto, Raju, Shah, Hyman: "Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47370-5, 2003 (PubMed).

Zhou, Su, Li, Liu, Ryder, Wu, Gonzalez-DeWhitt, Gelfanova, Hale, May, Paul, Ni: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Murakami, Irie, Morimoto, Ohigashi, Shindo, Nagao, Shimizu, Shirasawa: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Kim, Kim, Lee, Choi, Kim, Huh, Lee, Han, Rha: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).

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