SULT1A1 Antikörper (AA 128-160)

Produktnummer ABIN389136

Produktdetails anti-SULT1A1 Antikörper

Target: SULT1A1 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 1 (SULT1A1))

Bindungsspezifität: AA 128-160

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SULT1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Pr

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SULT1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-160 amino acids from the Central region of human SULT1A1.

Klon: RB05112

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu SULT1A1

Target: SULT1A1 (Sulfotransferase Family, Cytosolic, 1A, Phenol-Preferring, Member 1 (SULT1A1))

Andere Bezeichnung: SULT1A1 (SULT1A1 Produkte)

Synonyme: HAST1/HAST2 antikoerper, P-PST antikoerper, PST antikoerper, ST1A1 antikoerper, ST1A3 antikoerper, STP antikoerper, STP1 antikoerper, TSPST1 antikoerper, AI266890 antikoerper, Stp antikoerper, Stp1 antikoerper, ASTIV antikoerper, Mx-ST antikoerper, PST-1 antikoerper, St1a1 antikoerper, Stm antikoerper, Sult1a3 antikoerper, pst antikoerper, st1a3 antikoerper, stp antikoerper, stp1 antikoerper, tspst1 antikoerper, cSULT1A1 antikoerper, SULT1A2 antikoerper, SULT1A1 antikoerper, SIAT8-D antikoerper, ST8SiaIV antikoerper, Siat8d antikoerper, PST1 antikoerper, SIAT8D antikoerper, ST8SIA-IV antikoerper, sulfotransferase family 1A member 1 antikoerper, sulfotransferase family 1A, phenol-preferring, member 1 antikoerper, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 antikoerper, sulfotransferase family 1A member 1 S homeolog antikoerper, sulfotransferase 1A1 antikoerper, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 antikoerper, SULT1A1 antikoerper, Sult1a1 antikoerper, sult1a1 antikoerper, sult1a1.S antikoerper, LOC704658 antikoerper, LOC709318 antikoerper, St8sia4 antikoerper, ST8SIA4 antikoerper, LOC100064221 antikoerper

Hintergrund: Sulphation is a significant detoxification pathway for diverse xenobiotics, yet this modification also plays an important role in the metabolism and bioactivation of many dietary and environmental mutagens, including heterocyclic amines implicated in the pathogenesis of several cancers. A major human sulfotransferase, SULT1A1, metabolizes and/or bioactivates many endogenous compounds and is implicated in a range of cancers because of its ability to transform xenobiotics to cellular mutagens and carcinogens. Genetic polymorphisms in human sulfotransferase 1A1 SULT1A1 have a major impact on SULT1A1 enzyme activity and affect the risk for cancer development in humans. A G--->A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene has been identified (SULT1A1*2), and individuals homozygous for the His allele have a markedly lower activity and stability of this enzyme than those with the high activity SULT1A1*1 allozyme, which has been associated with protection against dietary toxins and reduced susceptibility to colorectal and breast cancers.There is an increasing incidence of SULT1A1*1 homozygosity and decreasing incidence of SULT1A1*2 homozygosity with increasing age, indicating a potential association of SULT1A1*1 allozyme(s) with protection against cell and/or tissue damage during aging. CLN3, the locus for Batten disease, maps to the same region 16p12.1-p11.2 as SULT12A1, making SULT1A1 a candidate gene for this disorder.

Molekulargewicht: 34165

Gen-ID: 6817

NCBI Accession: NP_001046, NP_803565, NP_803566, NP_803878, NP_803880

UniProt: P50225